PD-L1 Recombinant Rabbit mAb (SDT-R017)
SKU: 91282035779

PD-L1 Recombinant Rabbit mAb (SDT-R017)

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Description

PD-L1 Recombinant Rabbit mAb (SDT-R017)Product Specification Host Rabbit Antigen PD L1 Synonyms Programmed cell death 1 ligand 1, CD274, B7 H1 Immunogen N A Location Membrane Accession Q9NZQ7 Clone Number SDT R017 Antibody Type Rabbit mAb Application WB, IHC P, IF Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt reconstitution, 20 C as

Product Specification


Host Rabbit
Antigen PD-L1
Synonyms Programmed cell death 1 ligand 1, CD274, B7-H1
Immunogen N/A
Location Membrane
Accession Q9NZQ7
Clone Number SDT-R017
Antibody Type Rabbit mAb
Application WB, IHC-P, IF
Reactivity Hu
Purification Protein A
Concentration 0.5 mg/ml
Physical Appearance Liquid
Storage Buffer PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage 12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
IHC-P 1:500 null
WB 1:1000 null
IF 1:100 null

Background

Programmed death-ligand 1 (PD-L1) also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1) is a protein that in humans is encoded by the CD274 gene. Programmed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the adaptive arm of immune systems during particular events such as pregnancy, tissue allografts, autoimmune disease and other disease states such as hepatitis. The binding of PD-L1 to the inhibitory checkpoint molecule PD-1 transmits an inhibitory signal based on interaction with phosphatases (SHP-1 or SHP-2) via Immunoreceptor Tyrosine-Based Switch Motif (ITSM). This reduces the proliferation of antigen-specific T-cells in lymph nodes, while simultaneously reducing apoptosis in regulatory T cells (anti-inflammatory, suppressive T cells) - further mediated by a lower regulation of the gene Bcl-2. Upregulation of PD-L1 on immune cells (especially myeloid cells) can also lead to formation of an immunosuppressive environment in a highly localized manner that also allow the cancer cells to proliferate.
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SKU: 91282035779

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4.5 ★★★★★
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Product Reviews
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September
Belleville, US
★★★★★ 5
too advanced for 18month old, but great book!
Format: Paperback
I love Richard Scarry! I bought this book for my 18 month old, who we are trying to teach to say please and thank you. Unfortunately this book is just way too advanced for her. It's full on stories rather than short pieces. I know, the suggested age was older but that is true for a lot of books that really can be enjoyed by younger tots. This one will be put away for at least another 6 months, and then kept on the shelf of "appropriate" but not in her board book box. However, I really like that she can now say "Lowly" :) Richard Scarry is one of my favorite authors/illustrators from childhood and I'm glad to have this book. It just is beyond the reach of my LO at this age.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on September 8, 2015
N
Verified Purchase
Nancy Hicks
Waukegan, US
★★★★★ 5
Baby loves this book
Format: Board book
Lots of pictures for a 17 month old to talk about and point to
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Reviewed in the United States on October 12, 2025
N
Verified Purchase
Nancy T.
Battle Creek, US
★★★★★ 5
A must for a Richard Scarry book collection.
Format: Board book
Another great Richard Scarry book! The illustrations and words are wonderful for my 1 year old grandson.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on August 8, 2025
S
Verified Purchase
Shopaholic
West Palm Beach, US
★★★★★ 5
A Favorite!
Format: Board book
Having loved Richard Scarry books as a child in the 70's, I was thrilled when he regained popularity in the 90's when we were raising our children. Now I get to share this beloved classic with my granddaughter. She LOVES her Richard Scarry books and this one is wonderful. Every page has so many beautifully illustrated details so there are always new things to look at and discover. She is 18 months old and the Richard Scarry books have been instrumental in helping her vocabulary, now over 200 words. Highly recommend that you add this awesome book to your baby's library and read, read, read to your baby every chance you get!
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Reviewed in the United States on November 19, 2023
E
Verified Purchase
ex
Whiting, US
★★★★★ 5
Time tested classics for children
Format: Board book
Love Richard Scarry books for toddlers and above! The board books are great for younger ones—kids are enthralled by the illustrations—-parents by the educational content. Classics!
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Reviewed in the United States on June 7, 2025

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