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Description
Human RBP4 , His tagProduct Specification Species Human Synonyms Plasma retinol binding protein (PRBP; RBP) Accession P02753 Amino Acid Sequence Protein sequence(P02753, Glu19 Leu201, with C 10*His) ERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDETGQMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRLLNLDGTCADSYSFVFSRDPNGLPPEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSERNLLGGGGSHHHHHHHHHH Expression System HEK293 Molecular Weight Theoretical: 22. 7kDa Actual: 24kDa
Product Specification
| Species | Human |
| Synonyms | Plasma retinol-binding protein (PRBP; RBP) |
| Accession | P02753 |
| Amino Acid Sequence | Protein sequence(P02753, Glu19-Leu201, with C-10*His) ERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDETGQMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRLLNLDGTCADSYSFVFSRDPNGLPPEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSERNLLGGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | Theoretical:22.7kDa Actual:24kDa |
| Purity | ＞90% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, 1mM EDTA, pH7.4. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. 6 months, -20 to -70 °C under sterile conditions after reconstitution. 1 week, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles. |
Background
Retinol binding protein 4, also known as RBP4, is a transporter protein[5] for retinol (vitamin A alcohol). It is mainly, though not exclusively, synthesized in the liver and circulates in the bloodstream as a hepatokine bound to retinol in a complex with transthyretin. RBP4 has been a drug target for ophthalmology research due to its role in vision. RBP4 may also be involved in metabolic diseases as suggested by recent studies. Retinol-binding protein 4 in urine (uRBP4) is a functional biomarker of disease of the proximal renal tubule1. When proximal tubular dysfunction interferes with reabsorption of proteins filtered by the renal glomerulus, striking increases of uRBP4 are found.
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