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Description
CD47 Recombinant Rabbit mAb (SDT-R121)Product Specification Host Rabbit Antigen CD47 Synonyms Leukocyte surface antigen CD47, IAP, MER6 Immunogen N A Location Cell membrane Accession Q08722 Clone Number SDT R121 Antibody Type Rabbit mAb Application WB, IHC P Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt reconstitution, 20 C as
Product Specification
| Host | Rabbit |
| Antigen | CD47 |
| Synonyms | Leukocyte surface antigen CD47, IAP, MER6 |
| Immunogen | N/A |
| Location | Cell membrane |
| Accession | Q08722 |
| Clone Number | SDT-R121 |
| Antibody Type | Rabbit mAb |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | null |
| IHC-P | 1:200 | null |
Background
The transmembrane protein, CD47, is recognized as an important innate immune checkpoint, and CD47-targeted drugs have been in development with the aim of inhibiting the interaction between CD47 and the regulatory glycoprotein SIRPα, for antitumor immunotherapy. Further, CD47 mediates other essential functions such as cell proliferation, caspase-independent cell death (CICD), angiogenesis and other integrin-activation-dependent cell phenotypic responses when bound to thrombospondin-1 (TSP-1) or other ligands. Mounting strategies that target CD47 have been developed in pre-clinical and clinical trials, including antibodies, small molecules, siRNAs, and peptides, and some of them have shown great promise in cancer treatment [PMID: 35931392].
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4.1 ★★★★★
Based on 1639 reviews
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Product Reviews
★★★★★ 3
New Type of Sports Romance!
Format: Kindle, Format: Kindle
Instagram: @notyourkindlehistory
Burnout by Rebecca Jenshak
Rating: 3.5
Spice: 3.5
Tropes:
- Gymnast x motocross rider
- Training together
- Tattooed hero
- College romance
- Ton of Banter
My Review
Okay… I’m not even sure how to start this review so I’m just going to explain my 3.5 rating. I want to begin saying, there really wasn’t anything that made this book bad. I have read previous books by Rebecca Jenshak, and I LOVED them, rated them 4 or 5 stars, but for some reason, this book took me about 35-40% of the way through to finally get into it and enjoy it. Once I got past that point, I absolutely loved it. I’m not sure if it was a mood I was in, or just that it was a completely different type of sports romance, but something just didn’t grab my attention soon enough. I loved Avery and Knox, two complete opposite kind of people, which made for a ton of banter. I loved that we were able to get inside of the head of Avery, an Olympic gymnast, who was recovering from an injury, and see what that process of the road to recovery and competing again at 100% looked like from a mental stand point. Knox was this character that you got immediate bad boy, I don’t do relationships and just hook up vibes from, but slowly throughout the book you can see Avery and Knox going back and forth and breaking each-others walls down. They began hanging out more and doing more things together, but didn’t want to define what they had because it worked for them and what they needed at the time. This book had different aspects of a relationship that you don’t see in other romance books, such as long distance. I thought the end of this book was left more open ended than closed, and I felt it just kind of ended, or the epilogue wasn’t really a cherry on top, it was more so just the sprinkles. BUT, overall, I would recommend this book to read to others; the spice in this book was AMAZING (there may or may not be a spicy motorcycle scene hehe), the banter was great, we really got a feel and understanding of each character too. I wonder if I read it again, or read other books in the universe to get some background on this story, maybe my mind will change on my rating; but for now it’s a solid 3.5 for me.
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Reviewed in the United States on June 13, 2024
★★★★★ 5
Good book
Format: Kindle
This is my first book by this author and I loved it so much. Such a cute story. I absolutely loved reading Knox and Avery's story. Knox is a motocross racer and Avery is a gymnast. Knox lost his spot with his team for not being a team player. He is bummed out because racing has been all he really wanted to do. Knox lost his mom when he was a teenager and he took on a pretty big responsibility helping take care of his brothers. He has an older brother who went to college and then two younger ones that also ended up going to college and then there's the youngest one that's a senior in high school. Knox is a great big brother but really wants to race so his friend Colter, who does freestyle tricks on bikes, talks him into trying to do trick riding too.
Avery hurt her knee a bit ago which she did therapy for but is really aware of her knee now and just doesn't have the confidence like she used too. Avery goes out with her friend to a party to get out of her head and there she sees Knox. He's on his bike but he almost got her and from there it starts there relationship of having snarky comments to each other. Avery helped Knox' friend Colter do some gymnastic workouts to get his strength and learn some tricks for his trick riding. Colter recommends Knox work with her too. Knox takes him up on this because Knox needs this to show people in motocross racing he can be a team player.
Knox and Avery end up getting a long better and you can feel the chemistry between the two but both don't want a relationship for different reasons. Things heat up between the two of them. Lots more happen in this book and you will want to read to find out what that is. Will Avery and Knox be able to get over their fears and be together? Have to read to find out. Thank you Rebecca Jenshak for this book.
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Reviewed in the United States on April 28, 2024
★★★★★ 4
Solid start to a new series! Love the Holland brothers
Format: Kindle
There is one thing I've learned when I read Rebecca books: I either love them and am obsessed (looking at you "Tutoring the Player") or I really like them, but feel like there's something missing. And this book fell in the latter.
Ok, so, I did really enjoy this book. I was so excited to get to know the younger Hollands after meeting Hendrick in "Tempting the Player." I was so intrigued by their dynamics, so when I saw those Holland brothers were getting a series, I was SOLD. And I'm not gonna lie, I really enjoyed grumpy and closed-off Knox Holland. The relationship he has with his brothers is special, but especially the one he has with his youngest brother, Flynn. And that, alone, made me fall in love with him. But watching as Avery wore him down, without even trying, was the best. And how he didn't even realize it was happening? Even better.
Avery was awesome! I LOVED her! She's had a rough go after an injury at the end of her freshman year at Valley U, and it's really rocked her confidence as she works to come back. She was funny and the way she fit in with the Holland brothers was perfect... especially the way she cared for Flynn. I loved the banter and way she goes back and forth with Brogan too. That guy is hilarious. She just...fits, and they all can see it.
The only thing that kept this from a 5 star for me was that it just felt like it...ended. We have the conflict, we get back together, but then, it's a super quick last chapter, no epilogue, and it's over. I really wanted to see at least a little more of them as an official couple. I do love how you could see how close she and Flynn are in the last chapter. And how even though the others have moved on to other things (Archer and Brogan the NFL, Henny and Jane are married), they're still such a tight family unit.
There is a super short but sweet epilogue you can get at the end of the book if you sign up for Rebecca's newsletter (which, duh, I already get because I do love her books!). Overall, I really enjoyed this book, but I have to say, the level of excitement I have for Archer and Flynn, but Archer especially, is next level!
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Reviewed in the United States on June 22, 2025
★★★★★ 5
I loved it so much!!!
Format: Kindle
I've had this one on my TBR lis forever and been meaning to get to it. Considering I picked up the ebook last year not long after it came out. I can't believe I let this one sit on my kindle for as long as I did. I ended up starting and finishing in just one afternoon absolutely hooked on Avery and Knox. They has this connection that just works even if they are to stubborn to see what's happening. I loved the whole bad buy meets the good girl in this sweet steamy enemies to lovers romance.
The author does a beautiful job creating a captivating story with characters you can't help falling in love with. This is my first book by the author and I'm a fan as I enjoyed every moment of Avery and Knox's story. I loved that we get to know a little bit of Knox's brothers as the series is about them and can't wait to devour there stories too. Highly recommend the characters are engaging and the story is perfectly balanced with just the right amount of romance. This one made me want to look up the riding that Knox did off season and it's impressive. I loved it!!! One of my favorite books of 2025.
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Reviewed in the United States on May 5, 2025
★★★★★ 4
Good Sports Romance
Format: Kindle
Knox is a motor cross racer and Avery is a gymnast. Seems like opposites, right? But there is much more common ground. This couple is fantastic together and love the friends and family vibes. Can’t wait to read the rest of the books in the Holland Brothers series and go back to read Hendrick and Jane’s story.
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Reviewed in the United States on May 23, 2026
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