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Description
APC Rat Anti-Mouse MERTK Antibody (S-R603)Product Specification Host Rat Antigen MERTK Synonyms Tyrosine protein kinase Mer; Proto oncogene c Mer; Receptor tyrosine kinase MerTK; Mer; Mertk Location Cell membrane Accession Q60805 Clone Number S R603 Antibody Type Rat mAb Isotype IgG2a,k Application FCM Reactivity Ms Positive Sample C57BL 6 mouse peritoneal exudates cells Purification Protein G Concentration 0. 05mg ml Conjugation APC Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0.
Product Specification
| Host | Rat |
| Antigen | MERTK |
| Synonyms | Tyrosine-protein kinase Mer; Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK; Mer; Mertk |
| Location | Cell membrane |
| Accession | Q60805 |
| Clone Number | S-R603 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse peritoneal exudates cells |
| Purification | Protein G |
| Concentration | 0.05mg/ml |
| Conjugation | APC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
MERTK, also known as MER proto-oncogene tyrosine kinase, is a receptor tyrosine kinase and a member of the TAM (TYRO3, AXL, MERTK) family. It plays crucial roles in various physiological processes, including cell survival, migration, differentiation, and the phagocytosis of apoptotic cells, a process known as efferocytosis. MERTK is expressed in multiple tissues, such as macrophages and retinal pigment epithelial cells, and is involved in regulating immune responses and maintaining tissue homeostasis. In the immune system, MERTK helps macrophages clear apoptotic cells and inhibits the innate immune response by activating STAT1, which induces the production of suppressors of cytokine signaling (SOCS1 and SOCS3). Abnormal expression of MERTK has been linked to several diseases, including retinitis pigmentosa and certain cancers, making it a potential therapeutic target in cancer treatment.
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