Pure Fisetin - 250 mg, 60 capsules

The Ultimate Weapon Against Zombie Cells

• Powerful 5-day cellular reset*¹
• Clear out “zombie” senescent cells*^1-2
• Restore and revitalize tissues*^1-3
• Unlock youthful aging from within*^1-4

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Why Fisetin?
Fisetin is a powerful plant flavonoid that supports the body's natural ability to eliminate senescent cells—old dysfunctional cells that accumulate with age and contribute to age-related decline. Groundbreaking research reveals fisetin’s ability to promote deep cellular renewal, supporting full-body rejuvenation and long-term vitality.*^1-5

• Ultra-Pure Extract: Sourced from the stems of the Japanese fruit wax tree (Rhus succedanea) for exceptional purity and potency.
• Potent Senolytic: One of the most effective compounds for eliminating senescent cells, a key driver of aging.*^1-5
•  Multiple Longevity Benefits: Supports antioxidant defenses, activates autophagy and SIRT1, and helps manage SASP factors—compounds released by senescent cells that can spread cellular dysfunction.*^5-9

What Makes Ours Better?

• Extra Strength Formula: 1,500 mg "Senolytic Dose"*³ 
  
• Short-Term Protocol: Designed by doctors to mimic the most effective senolytic protocols studied in research.*^1,3  
  
• Triple Lab Tested: Subjected to three rounds of independent third-party lab testing to ensure unmatched potency and purity.
  
• Full Transparency: In an industry full of misleading claims, we publish our third-party lab results—so you always know exactly what’s in every bottle.
• Manufactured in the USA: Made in FDA-regulated, GMP-certified facilities, adhering to the highest quality and safety standards.
• 100-Day Risk-Free Guarantee: We’re confident you’ll love our product. If you’re not satisfied, contact our Santa Barbara, CA office for a full refund within 100 days—no hassle, no questions asked.

Fisetin is a naturally occurring flavonoid known for its distinctive yellow color. Its name comes from the German word “fisetholz,” referring to a traditional yellow dye. In plants, fisetin plays a key role in defending against environmental stressors like UV radiation and pathogens.

Beyond its role in plants, fisetin has gained considerable scientific interest for its potential to support human health. It is now recognized as one of the most promising senolytic compounds for healthy aging. A groundbreaking 2018 study identified fisetin as the most potent senolytic agent among 10 flavonoid polyphenols, including quercetin, resveratrol, curcumin, and apigenin. The study demonstrated that fisetin effectively reduced senescent cell markers in vitro while restoring youthful tissue function in vivo.*²

Early research on fisetin as a senolytic involved high doses of around 100 mg per kg of body weight—equating to approximately 6,800 mg for an average adult. However, more recent studies indicate that much lower doses of around 20 mg per kg (about 1,400 mg for an average adult) are effective. Current clinical trials are exploring fisetin's full potential at this optimized dose.*^1,3,9

A standout feature of senolytic compounds like fisetin is their unique dosing strategy. Studies show that high doses taken over short periods are the most effective method for clearing senescent cells. This "pulsed dosing" or “hit-and-run” approach is the gold standard in research, supporting the removal of dysfunctional cells and supporting overall cellular health.*¹

Introducing: The 5-Day Cellular Reset*¹
To harness fisetin’s powerful senolytic benefits, we’ve designed the ProHealth 5-Day Cellular Reset protocol aimed at optimizing its role in supporting healthy aging:

• Take six (6) capsules of Pure Fisetin daily for 5 consecutive days.
• Discontinue use on day 6.
• Wait 4 weeks before repeating the cycle.  

This strategic "hit-and-run" approach supports the body’s natural ability to clear out senescent cells. The protocol can be followed monthly or less frequently, depending on individual needs.*^1-5,9

Note: If this protocol feels too intensive, you can opt for one capsule of ProHealth Pure Fisetin daily for ongoing support.*⁶

The Ultimate Weapon Against Zombie Cells*

Potent Senolytic Action^*1-5
The term "senolytic" comes from the Latin words senex (old) and lytic (destroying). Senolytics are compounds that help the body clear senescent cells—cells that have stopped dividing and contribute to aging. The buildup of these dysfunctional cells is a key hallmark of aging known as cellular senescence, which drives inflammation, impairs tissue function, and reduces the body's ability to regenerate. By promoting the removal of senescent cells, senolytic compounds like fisetin support cellular health and help counteract age-related decline.*^1-5,10

Clear Out "Zombie" Senescent Cells* ^*1-5,9
Senolytics, including fisetin, selectively target senescent cells while leaving healthy cells unharmed. They work by disrupting Senescent Cell Anti-Apoptotic Pathways (SCAPs), which triggers apoptosis—the body’s natural process for removing damaged, dysfunctional cells. This process paves the way for healthier, more vibrant cells to thrive.*^1-5,9

Activate Autophagy*^5,7
Fisetin activates autophagy, the body’s built-in recycling process that removes damaged cell components and supports cellular renewal. By enhancing this natural repair mechanism, fisetin helps maintain healthy cell function and promote healthy aging.*^5,7

Boost SIRT1 Activity*^8,11
Fisetin activates the SIRT1 “longevity gene,” boosting cellular repair, function, and resilience to help cells operate at their peak, just like in youth. While fasting and calorie restriction naturally stimulate SIRT1, fisetin can act as a potent “fasting mimetic,” increasing SIRT1 activity without the need for caloric restriction.*^8,11

Food Alone Isn’t Enough
Fisetin is naturally present in foods like strawberries, apples, grapes, and cucumbers. However, the average diet provides only about 0.4 mg of fisetin per day—far below the senolytic threshold. To reach an effective dose through food alone, you’d need to consume an impractical amount of fruits and vegetables. That's why concentrated fisetin supplements are the most efficient way to achieve optimal benefits.*¹²

Pure Fisetin is a Breakthrough in Senolytic Science*
Experience the groundbreaking benefits of fisetin with ProHealth Pure Fisetin. At the leading edge of longevity science, fisetin is one ingredient that can have profoundly positive impacts on the aging process, by helping to address aging at the cellular level.*^1-5,7,9

Order now and join the 200,000+ people who trust ProHealth Pure Fisetin for their cellular health!

Ingredients:

• Fisetin: A potent polyphenol compound that helps the body clear senescent cells.*^1-5,9

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

References:

¹ Mahoney SA et al. Aging Cell. 2024;23(3):e14060. 
² Yousefzadeh MJ et al. EBioMedicine. 2018;36:18-28. 
³ Zhao R et al. Peer J. 2023;11:e16463.
⁴ Lorenzo EC et al. Front Aging. 2023;4:1161799.
⁵ De Sousa Lages A et al. Int J Mol Sci. 2022;23(17):9957. 
⁶ Khan N et al. Antioxid Redox Signal. 2013;19(2):151-162. 
⁷ Zheng LT et al. Int Immunopharmacol. 2008;8(3):484-494. 
⁸ Wiciński M et al. Nutrients. 2023;15(16):3578. 
⁹ Tavanier J et al. Mech Ageing Dev. 2024;222:111995.
¹⁰ López-Otín C et al. Cell. 2023;186(2):243-278. 
¹¹ Xing X et al. Mol Basel Switz. 2023;28(14):5533.  
¹² Kimira M et al. J Epidemiol. 1998;8(3):168-175.