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Description
Human PAI-1, His tagProduct Specification Species Human Synonyms plasminogen activator inhibitor 1; endothelial plasminogen activator inhibitor; serpin E1 Accession P05121 Amino Acid Sequence Protein sequence(P05121, Val24 Pro402, with C 10*His)
Product Specification
| Species | Human |
| Synonyms | plasminogen activator inhibitor-1; endothelial plasminogen activator inhibitor; serpin E1 |
| Accession | P05121 |
| Amino Acid Sequence | Protein sequence(P05121, Val24-Pro402, with C-10*His) |
| Expression System | HEK293 |
| Molecular Weight | Theoretical: 44.4kDa Actual: 48kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage |
12 months from date of receipt, -20 ℃ to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles. |
Background
Plasminogen activator inhibitor-1 (PAI-1), a member of the serine protease inhibitor (serpin) superfamily with antiprotease activity, is the main physiological inhibitor of tissue-type (tPA) and urokinase-type (uPA) plasminogen activators (PAs). Apart from being crucially involved in fibrinolysis and wound healing, PAI-1 plays a pivotal role in various acute and chronic pathophysiological processes, including cardiovascular disease, tissue fibrosis, cancer, and age-related diseases.
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