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Description
CD8α Mouse mAb(SDT-126-8.3)Product Specification Host Mouse Antigen CD8a Synonyms T lymphocyte differentiation antigen T8 Leu 2, T cell surface glycoprotein CD8 alpha chain, MAL Immunogen Synthetic Peptide Location Membrane Accession P01732 Clone Number SDT 126 8. 3 Antibody Type Mouse mAb Isotype IgG1,k Application IHC P, ICC, IF Reactivity Hu Purification Protein G Concentration 1mg ml Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05%BSA, 0. 03% Proclin 300
Product Specification
| Host | Mouse |
| Antigen | CD8a |
| Synonyms | T-lymphocyte differentiation antigen T8/Leu-2, T-cell surface glycoprotein CD8 alpha chain, MAL |
| Immunogen | Synthetic Peptide |
| Location | Membrane |
| Accession | P01732 |
| Clone Number | SDT-126-8.3 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | IHC-P, ICC, IF |
| Reactivity | Hu |
| Purification | Protein G |
| Concentration | 1mg/ml |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Background
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen-presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain isoforms. Two alternative transcripts encoding distinct isoforms, one membrane associated and one secreted, have been identified
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4.7 ★★★★★
Based on 265 reviews
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Product Reviews
★★★★★ 2
Cute? Yes! Durable? Not so much…
Size: Large (Pack of 1), Color: Green Gecko, Size: Large (Pack of 1), Color: Green Gecko
Upon opening this toy I was hopeful that it would last my dog (medium size beagle mix) quite a while. While he enjoyed it, he was able to start ripping it up less than 24 hours after getting it. Now 10 days later, he’s completely destroyed it. He was able to rip open all layers of material, pull them apart, and tear all the squeakers out. While the squeakers are large, they could be a choking hazard for a large dog. Based on the advertised “durability” of this toy and how little time it lasted my dog, I would not purchase it again.
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Reviewed in the United States on February 3, 2026
★★★★★ 4
German Shepard destroy
Size: Medium (Pack of 1), Color: Orange Gecko, Size: Medium (Pack of 1), Color: Orange Gecko
We've been playing with this lizard for a month now and the fabric has been ripped off within first few days but my dog hasn't got to the squeakers yet.
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Reviewed in the United States on June 10, 2026
★★★★★ 5
This worm, pretty sure it’s a worm and not a snake, can take a lot of abuse.
Size: X-Large (Pack of 1), Color: Blue Snake, Size: X-Large (Pack of 1), Color: Blue Snake
Snake, worm, whatever, my dog doesn’t care, she loves it all the same. My little friend can be kinda rough with her toys. This is no exception. The pictures are from roughly one month of giving it to her and include playing with it at least every other day or so. The top is holding up well, but the bottom has taken some damage, and two of the squeakers have long since been destroyed. Despite this, my dog still loves playing with it. We normally play tug of war together, but on her own she chews at it to get to the squeakers inside, which she promptly destroys, which I’m totally fine with, as quiet toys are much preferred, by me, not her. I believe there are 4 in the XL size that we got. We’ve had a few of these in the past. We tend to get about 6 months out of them. After she “lovingly” removes the squeakers, she doesn’t chew on it much, and we just use it for tug of war, but at that point she’s done enough damage to the underside that its time is limited. But, as it’s pretty low priced, for the time and enjoyment we do get out of it, it’s very much worth it. I do need to clarify, the durability is actually quite good, I don’t fault the product as at all, it’s just my dog is equally as good with destruction, but it should be noted this toy does last much longer than most of her victims. The color, (we got the blue and green) is also very vivid and nice, as is the texture. We’ll be purchasing again.
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Reviewed in the United States on September 23, 2024
★★★★★ 5
Awesome toy!
Size: X-Large (Pack of 1), Color: Blue Snake
My pitbull Stella loves these! Ive bought her two of the smaller snake toys in the past and she Absolutly loves them! The first one lasted about 6 months which is a lifetime compared to how long her other toys last lol and the second one lasted about the same. This time I decided to get the XL version. It has 6 squeakers instead of 3 like the smaller versions. I picked the teal and purple colors and it's like 43 inches long I think. Its the same length as her and shes a large size dog. She loves this thing! Its so cute watching her squeak each of the squeakers with her nose.
While this is a great toy it is not chew proof. In fact its quite easy for an experienced chewer to get into this toy. It is relatively strong but it wont stand a chance with a power chewer. Like I said this is the third one of these I have bought in roughly a year. They do last longer then more soft toys I will give them that. This is the only soft toy she has not destroyed in 5 mins. But after a week or so at least one squeaker will be missing.
For the average dog one of these snake toys will last a really long time and they are fun to play with. We play tug of war and fetch with it. Stella also loves when I squeak the toy she will squeak it back and we'll go back and forth for hours lol. One last thing it is loud! If noisy toys bug you, don't get this. The sqeakers are industrial strength lol
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Reviewed in the United States on February 7, 2021
★★★★★ 4
Durable toy but definitely NOT invincible
Size: Medium (Pack of 1), Color: Orange Gecko
BACKGROUND
I have two labradors and, with my friends dogs over, we have a combined combination of five labradors at a time. If you have seen the film "Marley & Me" then you will understand our dogs. They tear through concrete, dry wall, and, well, just about anything they can get their paws and mouths on. It is very important to have plenty of toys for them to keep pre-occupied as most of the destruction is caused by dogs that are bored.
Unfortunately, many items are not able to withstand this combined destructive force. I spotted these "Invincible" line of toys and thought they were worth a try. I ended up ordering basically one of every style and size.
APPEARANCE
The toys come in different sizes, colors, and shapes. The most common are the Gecko and the Snake. The toys are covered with a more durable cloth that is fuzzy and suppose to withstand quite a bit of chewing. Inside the toys are what are described as durable squeakers that, if punctured, will still squeak even after hours of being bitten and chewed upon. The larger the toy ordered, the more squeakers that are sewn into the toy.
RELIABILITY
I have to admit these toys did last about ten times as long as any other toy I have given my dogs. Unfortunately, nothing is indestructible. My dogs managed to find kinks in the lining of the toys that, once penetrated, will cause the toys to open leaving stuffing and squeak toys all over the place. The squeakers did withstand quite a bit of chewing before the squeaking went silent.
I noticed that the snake toy did last quite a bit longer than the gecko or the little dragon characters. The snake had separate compartments for the squeakers and so, if one was torn out, the others survived. On the Gecko once its middle section was torn open the squeakers were lost.
CUSTOMER SUPPORT
Not utilized
PROS:
++ Lasted about 10X times the length of time as other "invincible" toys
CONS:
++ They are not truly "invincible" and will be destroyed over time
CONCLUSION
The invincible line of toys did last a lot longer than most toys that I have purchased for my labradors. I would recommend the snake over the gecko or other styles. I have had to toss the geckos as they were shredded but the snakes are still with me to this day six months later. Also note, even though "Invincible" is in the title, these toys are definitely not although you will save an incredible amount purchasing these toys once and having a gradual destruction process versus having to buy new toys continuously over the same period of time that these lasted.
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Reviewed in the United States on October 18, 2012