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Description
human bsep vesicle kit hek293Das Human BSEP Vesicle Kit enthlt Inside out Membranvesikel aus HEK293 Zellen, die transient die Bile Salt Export Pump (BSEP ABCB11) berexprimieren. BSEP ist der primre hepatische Efflux Transporter fr Gallensalze und ein zentrales Zielprotein in der Risikoabschtzung fr medikamenteninduzierte Cholestase (DILI). Das Kit ist konform mit den FDA (2017) und EMA (2013) Leitlinien fr DDI Studien. Hergestellt von Cell4Pharma. Exklusiv im DACH Raum erhltlich
Das Human BSEP Vesicle Kit enthält Inside-out Membranvesikel aus HEK293-Zellen, die transient die Bile Salt Export Pump (BSEP / ABCB11) überexprimieren. BSEP ist der primäre hepatische Efflux-Transporter für Gallensalze und ein zentrales Zielprotein in der Risikoabschätzung für medikamenteninduzierte Cholestase (DILI). Das Kit ist konform mit den FDA (2017)- und EMA (2013) Leitlinien für DDI Studien.
Hergestellt von Cell4Pharma. Exklusiv im DACH-Raum erhältlich über SeamlessBio.
Transporter-Profil
Name: BSEP, Bile Salt Export Pump, ABCB11, ATP-bindende Kassette Unterfamilie B Mitglied 11
Gen: ABCB11
ATP/AMP-Ratio: >10 (garantiert)
Gewebsexpression: Kanalikuläre Plasmamembran der Hepatozyten
Erkrankungen: Erbliche und medikamenteninduzierte Cholestase (DILI)
Bekannte Substrate: Taurocholat, Pravastatin, Taurolithocholyl-3-Sulfat, konjugierte monovalente Gallensalze
In stock: Human, Katze, Hund
Kit-Inhalt (100 Reaktionen)
- Vesikel-Vial (100 Reaktionen), BSEP überexprimierende HEK293-abgeleitete Vesikel
- AMP-ATP-Lösung (100 mM), Cell4Pharma
- Assay-Puffer, Cell4Pharma
Anwendungen
- allensalztransport-Inhibitionsstudien (Cholestase-Risikoabschätzung)
- Drug-Induced Liver Injury (DILI) Screening
- Drug-Drug-Interaction-(DDI)-Studien gemäß FDA/EMA-Leitlinien
- Substratidentifikation für hepatische Efflux-Transporter
- High-Throughput-Screening (Radiolabel-, Fluoreszenz-, LC-MS-Detektion)
Regulatorische Konformität
Die Hemmung von BSEP ist ein etablierter Mechanismus der medikamenteninduzierten cholestatischen Leberschädigung. Die Bewertung der BSEP-Hemmung wird in den FDA (2017)- und EMA (2013)-DDI-Leitlinien als Teil des Transporter-Charakterisierungspakets für neue Molekülentitäten (NMEs) in der klinischen Entwicklung empfohlen.
Technische Spezifikationen
Wirtszelle: HEK293 (humane embryonale Nierenzelle)
Vesikeltyp: Inside-out-Membranvesikel
Format: 100 Reaktionen pro Kit
Detektion: Radiolabel / Fluoreszenz / LC-MS kompatibel
Lagerung: –80 °C
Verwandte Produkte
- Human Control Vesicle Kit (C4PVK009) – empfohlen als Negativkontrolle in BCRP-Transportassays
- Human MRP2 Vesicle Kit (C4PVK002) – for parallel hepatic efflux assessment
- Human BCRP Vesicle Kit (C4PVK006) – for complete efflux transporter panel
- ciPTEC-OAT1 Assay-Ready Cells – für zellbasierte Nephrotoxizitäts- und Transporterstudien
- Human Serum AB Male OTC (SeamlessBio) – zur Supplementierung von ciPTEC-Kulturmedien
Alle Produkte auf Anfrage.
Kontakt: [email protected] | Telefon: +49 851 37932226
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4.5 ★★★★★
Based on 1541 reviews
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Product Reviews
★★★★★ 5
An amazing, if sometimes dark, memoir of work, solitude, and taking a pragmatic path in life.
Format: Hardcover
What do you do, when your only viable financial prospects are to move to even more remote, cold, dark and desolate land where you are part of a corporate mining operation dredging sands for valuable resources, living onsite in a company owned dormitory? Beaton recalls all this in her memoir of her post-university time, where she was faced with this decision to either live and work the oil sands, or face a life of financial bondage trying to pay back student loans, a decision we see many of her own countrymen face as their only viable means to survive.
If you are familiar with Beaton's comic strip work, you'll see familiar reference to the genesis of it here, but Ducks is a far more serious graphic novel. Both engaging and often times bleak, Ducks gives a wonderful window into the reality of Canada's oil industry, and the humanity of the people, who are nothing more than cogs in a machine, that run it.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on December 7, 2023
★★★★★ 5
What is NOT to love about Lynda Barry?
Format: Paperback
I’ve been reading Lynda Barry since the 80s and am currently at work on a graphic novel, that I’m writing and illustrating. I have always believed in learning from the best and Barry has always been a favorite, from the creativity, recall and connections she makes with her work as well as with me (and I assume her other readers as well). This book delves into the connections of words and images, how to conjure and connect, especially with the whole creative vibe. She works with young people and the pipeline to that cerebral communication is appreciated and thought provoking as well, as my work will be geared to a younger audience. This is for anyone who interested in the process of sequential art, creating comics, characters, connecting with creative elements, it’s also a visually stunning book (again, the nerd in me, loved all the cross-references with the visual and other, using calligraphic and other historic, formal art elements along with the more personal character, visual creations and exercises. Thought-provoking and image inducing, indeed!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on September 2, 2020
★★★★★ 5
Lynda Barry is Awesome
Format: Kindle
This book is fantastic if you want to make comics by yourself or with a classroom. Barry packs in loads of experience teaching and making art. Her style of drawing is simple and straight forward. She uses a great method that empowers the reader to make art and share it.
I want to be half the teacher Barry is.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 1, 2024
★★★★★ 5
Creative outlets!
Format: Paperback
I LOVE following the activities in this book. Perfect for anyone who wants to draw but thinks they can’t, great exercises and fun for those creative blocks when you want to be creative but just can’t get it flowing.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 16, 2025
★★★★★ 5
This! Book! Rocks!
Format: Paperback
If you enjoy laughing, having fun with your friends and family, and doing cool stuff, you will love Lynda Barry's Making Comics. This is a thoughtful and complete recap of her live class at the University of Wisconsin, includes much of her substantial thought and philosophy on the role of image making in human evolution, and is full of her (and her students') amazing artwork; but it's also full of excessively FUN drawing exercises that are wonderful for sucky drawers as well as professional artists. We dig this book so bad!!! Best gift I've given myself in a million years!!!!!!!!!!!! Maybe I had a little bit forgotten how much I! Love! Lynda! Barry!!!!! So if you wish you could go move to Wisconsin and take her class like I do, instead just save the planet the extra greenhouse gases and get this book instead and do the class at your kitchen table with your friends!!! Maybe also order it from your local groovy independent bookstore so you can stick it to the man!!!
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Reviewed in the United States on January 2, 2020
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